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Effects of FK506 on Hippocampal CA1 Cells Following Transient Global IschemiaReperfusion in Wistar Rat
Joint Authors
Zarrindast, Mohammad Reza
Rahimian, Nasrin
Abolhassani, Farid
Movassaghi, Shabnam
Hassanzadeh, Gholamreza
Sharifi, Zahra-Nadia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus.
In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia.
Both common carotid arteries were occluded for 20 minutes followed by reperfusion.
In experimental group 1, FK506 (6 mg/kg) was given as a single dose exactly at the time of reperfusion.
In the second group, FK506 was administered at the beginning of reperfusion, followed by its administration intraperitoneally (IP) 6, 24, 48, and 72 hours after reperfusion.
FK506 failed to show neurotrophic effects on CA1 region when applied as a single dose of 6 mg/kg.
The cell number and size of the CA1 pyramidal cells were increased, also the number of cell death decreased in this region when FK506 was administrated 48 h after reperfusion.
This work supports the possible use of FK506 in treatment of ischemic brain damage.
American Psychological Association (APA)
Sharifi, Zahra-Nadia& Abolhassani, Farid& Zarrindast, Mohammad Reza& Movassaghi, Shabnam& Rahimian, Nasrin& Hassanzadeh, Gholamreza. 2011. Effects of FK506 on Hippocampal CA1 Cells Following Transient Global IschemiaReperfusion in Wistar Rat. Stroke Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499823
Modern Language Association (MLA)
Sharifi, Zahra-Nadia…[et al.]. Effects of FK506 on Hippocampal CA1 Cells Following Transient Global IschemiaReperfusion in Wistar Rat. Stroke Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499823
American Medical Association (AMA)
Sharifi, Zahra-Nadia& Abolhassani, Farid& Zarrindast, Mohammad Reza& Movassaghi, Shabnam& Rahimian, Nasrin& Hassanzadeh, Gholamreza. Effects of FK506 on Hippocampal CA1 Cells Following Transient Global IschemiaReperfusion in Wistar Rat. Stroke Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499823