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Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition
Joint Authors
Leal, Antonio
Pellicer, Antonio
Simón, Carlos
Herraiz, Sonia
Pellicer, Begoña
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cerebral palsy is a major neonatal handicap with unknown aetiology.
There is evidence that prenatal brain injury is the leading cause of CP.
Severe placental pathology accounts for a high percentage of cases.
Several factors predispose to prenatal brain damage but when and how they act is unclear.
The aim of this paper was to determine if hypoxia during pregnancy leads to damage in fetal brain and to evaluate the localization of this injury.
An animal model of chronic hypoxia produced by chronic administration of a nitric oxide synthase inhibitor (L-NAME) was used to evaluate apoptotic activity in fetal brains and to localize the most sensitive areas.
L-NAME reproduces a preeclamptic-like condition with increased blood pressure, proteinuria, growth restriction and intrauterine mortality.
Apoptotic activity was increased in L-NAME brains and the most sensitive areas were the subventricular and pallidum zone.
These results may explain the clinical features of CP.
Further studies are needed.
American Psychological Association (APA)
Pellicer, Begoña& Herraiz, Sonia& Leal, Antonio& Simón, Carlos& Pellicer, Antonio. 2010. Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition. Journal of Pregnancy،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499842
Modern Language Association (MLA)
Pellicer, Begoña…[et al.]. Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition. Journal of Pregnancy No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499842
American Medical Association (AMA)
Pellicer, Begoña& Herraiz, Sonia& Leal, Antonio& Simón, Carlos& Pellicer, Antonio. Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition. Journal of Pregnancy. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499842