Consequences of Neutralization on the Proliferation and Cytoskeletal Organization of Chondrocytes on Chitosan-Based Matrices
Joint Authors
Noriega, Sandra E.
Subramanian, Anuradha
Source
International Journal of Carbohydrate Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In tissue engineering strategies that seek to repair or regenerate native tissues, adhesion of cells to scaffolds or matrices is essential and has the potential to influence subsequent cellular events.
Our focus in this paper is to better understand the impact of cellular seeding and adhesion in the context of cartilage tissue engineering.
When scaffolds or surfaces are constructed from chitosan, the scaffolds must be first neutralized with sodium hydroxide and then washed copiously to render the surface, cell compatible.
We seek to better understand the effect of surface pretreatment regimen on the cellular response to chitosan-based surfaces.
In the present paper, sodium hydroxide concentration was varied between 0.1 M and 0.5 M and two different contacting times were studied: 10 minutes and 30 minutes.
The different pretreatment conditions were noted to affect cell proliferation, morphology, and cytoskeletal distribution.
An optimal set of experimental parameters were noted for improving cell growth on scaffolds.
American Psychological Association (APA)
Noriega, Sandra E.& Subramanian, Anuradha. 2011. Consequences of Neutralization on the Proliferation and Cytoskeletal Organization of Chondrocytes on Chitosan-Based Matrices. International Journal of Carbohydrate Chemistry،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-499864
Modern Language Association (MLA)
Noriega, Sandra E.& Subramanian, Anuradha. Consequences of Neutralization on the Proliferation and Cytoskeletal Organization of Chondrocytes on Chitosan-Based Matrices. International Journal of Carbohydrate Chemistry No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-499864
American Medical Association (AMA)
Noriega, Sandra E.& Subramanian, Anuradha. Consequences of Neutralization on the Proliferation and Cytoskeletal Organization of Chondrocytes on Chitosan-Based Matrices. International Journal of Carbohydrate Chemistry. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-499864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499864