Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection
Joint Authors
Terao, Yasuko
Ohta, Hiroyuki
Shintani, Yasushi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Stroke is a dynamic event in the brain involving heterogeneous cells.
There is now compelling clinical evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe ischemia can reduce subsequent neuronal death and improve behavioral recovery.
The neuroprotective role of hypothermia is also well established in experimental animals.
However, the mechanism of hypothermic neuroprotection remains unclear, although, presumably involves the ability of hypothermia to suppress a broad range of injurious factors.
In this paper, we addressed this issue by utilizing comprehensive gene and protein expression analyses of ischemic rat brains.
To predict precise target molecules, we took advantage of the therapeutic time window and duration of hypothermia necessary to exert neuroprotective effects.
We proposed that hypothermia contributes to protect neuroinflammation, and identified candidate molecules such as MIP-3α and Hsp70 that warrant further investigation as targets for therapeutic drugs acting as “hypothermia-like neuroprotectants.”
American Psychological Association (APA)
Shintani, Yasushi& Terao, Yasuko& Ohta, Hiroyuki. 2010. Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499877
Modern Language Association (MLA)
Shintani, Yasushi…[et al.]. Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection. Stroke Research and Treatment No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-499877
American Medical Association (AMA)
Shintani, Yasushi& Terao, Yasuko& Ohta, Hiroyuki. Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection. Stroke Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499877