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Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent
Joint Authors
Prashanth, Kudige Nagaraj
Basavaiah, Kanakapura
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Three simple and sensitive spectrophotometric methods are proposed for the determination of atenolol (ATN) in bulk drug and tablets.
The methods are based on the bromination of ATN by the bromine generated in situ by the action of the acid on the bromate–bromide mixture followed by the determination of unreacted bromine by reacting with a fixed amount of either meta-cresol purple (MCP) and measuring the absorbance at 540 nm (method A) and 445 nm (method B) or erioglaucine (EGC) and measuring the absorbance at 630 nm (method C).
Beer's law is valid within the concentration ranges of 1.0–20.0, 2.0–40.0 and 1.0–8.0 μg/mL for method A, method B and method C, respectively.
The calculated molar absorptivities were found to be 1.20×104, 4.51×103 and 3.46×104 L/mol⋅cm for method A, method B and method C, respectively.
Sandell’s sensitivity values, correlation coefficients, limits of detection and quantification are also reported.
Recovery results were statistically compared with those of a reference method by applying Student’s t- and F-test.
The novelty of the present study is the measurement of two different colors using MCP, that is, red-pink color of MCP in acid medium at 540 nm and yellowish-orange color of brominated MCP at 445 nm.
American Psychological Association (APA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura. 2012. Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-499882
Modern Language Association (MLA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura. Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-499882
American Medical Association (AMA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura. Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-499882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499882