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Antidiabetic Indian Plants : A Good Source of Potent Amylase Inhibitors
Joint Authors
Zinjarde, Smita S.
Bhat, Menakshi
Joshi, Bimba N.
Ravi Kumar, Ameeta
Bhargava, Shobha Y.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetes is known as a multifactorial disease.
The treatment of diabetes (Type II) is complicated due to the inherent patho-physiological factors related to this disease.
One of the complications of diabetes is post-prandial hyperglycemia (PPHG).
Glucosidase inhibitors, particularly α-amylase inhibitors are a class of compounds that helps in managing PPHG.
Six ethno-botanically known plants having antidiabetic property namely, Azadirachta indica Adr.
Juss.; Murraya koenigii (L.) Sprengel; Ocimum tenuflorum (L.) (syn: Sanctum); Syzygium cumini (L.) Skeels (syn: Eugenia jambolana); Linum usitatissimum (L.) and Bougainvillea spectabilis were tested for their ability to inhibit glucosidase activity.
The chloroform, methanol and aqueous extracts were prepared sequentially from either leaves or seeds of these plants.
It was observed that the chloroform extract of O.
tenuflorum; B.
spectabilis; M.
koenigii and S.
cumini have significant α-amylase inhibitory property.
Plants extracts were further tested against murine pancreatic, liver and small intestinal crude enzyme preparations for glucosidase inhibitory activity.
The three extracts of O.
tenuflorum and chloroform extract of M.
koenigi showed good inhibition of murine pancreatic and intestinal glucosidases as compared with acarbose, a known glucosidase inhibitor.
American Psychological Association (APA)
Bhat, Menakshi& Zinjarde, Smita S.& Bhargava, Shobha Y.& Ravi Kumar, Ameeta& Joshi, Bimba N.. 2011. Antidiabetic Indian Plants : A Good Source of Potent Amylase Inhibitors. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499887
Modern Language Association (MLA)
Bhat, Menakshi…[et al.]. Antidiabetic Indian Plants : A Good Source of Potent Amylase Inhibitors. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499887
American Medical Association (AMA)
Bhat, Menakshi& Zinjarde, Smita S.& Bhargava, Shobha Y.& Ravi Kumar, Ameeta& Joshi, Bimba N.. Antidiabetic Indian Plants : A Good Source of Potent Amylase Inhibitors. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499887