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Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection
Joint Authors
Molesworth-Kenyon, S. J.
Oakes, J. E.
Milam, A.
Popham, N.
Lausch, R. N.
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this study we show that murine and human neutrophils are capable of secreting IP-10 in response to communication from the HSV-1 infected cornea and that they do so in a time frame associated with the recruitment of CD8+ T cells and CXCR3-expressing cells.
Cellular markers were used to establish that neutrophil influx corresponded in time to peak IP-10 production, and cellular depletion confirmed neutrophils to be a significant source of IP-10 during HSV-1 corneal infection in mice.
A novel ex vivo model for human corneal tissue infection with HSV-1 was used to confirm that cells resident in the cornea are also capable of stimulating neutrophils to secrete IP-10.
Our results support the hypothesis that neutrophils play a key role in T-cell recruitment and control of viral replication during HSV-1 corneal infection through the production of the T-cell recruiting chemokine IP-10.
American Psychological Association (APA)
Molesworth-Kenyon, S. J.& Popham, N.& Milam, A.& Oakes, J. E.& Lausch, R. N.. 2012. Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-499900
Modern Language Association (MLA)
Molesworth-Kenyon, S. J.…[et al.]. Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection. International Journal of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-499900
American Medical Association (AMA)
Molesworth-Kenyon, S. J.& Popham, N.& Milam, A.& Oakes, J. E.& Lausch, R. N.. Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-499900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499900