Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin : Effect on Vascular and Neural Complications
Joint Authors
Yorek, Mark A.
Dake, Brian
Davidson, Eric P.
Coppey, Lawrence J.
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We sought to determine the effect of dipeptidyl peptidase IV (DPP-IV) inhibition on streptozotocin diabetes-induced vascular and neural dysfunction.
After 4 weeks of untreated diabetes, rats were treated for 12 weeks with Alogliptin (DPP-IV inhibitor).
Diabetes caused a slowing of motor and sensory nerve conduction velocity, thermal hypoalgesia, reduction in intraepidermal nerve fiber density in the hindpaw, and impairment in vascular relaxation to acetylcholine and calcitonin gene-related peptide in epineurial arterioles.
Treatment significantly improved motor nerve conduction velocity and thermal response latency.
Sensory nerve conduction velocity was marginally improved with treatment of diabetic rats, and treatment did not improve the decrease in intraepidermal nerve fiber density.
Vascular relaxation by epineurial arterioles to calcitonin gene-related peptide but not acetylcholine was significantly improved with treatment.
These studies suggest that some but not all vascular and neural complications associated with type 1 diabetes can be improved with the inhibition of DPP-IV activity.
American Psychological Association (APA)
Davidson, Eric P.& Coppey, Lawrence J.& Dake, Brian& Yorek, Mark A.. 2011. Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin : Effect on Vascular and Neural Complications. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-499913
Modern Language Association (MLA)
Davidson, Eric P.…[et al.]. Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin : Effect on Vascular and Neural Complications. Experimental Diabetes Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-499913
American Medical Association (AMA)
Davidson, Eric P.& Coppey, Lawrence J.& Dake, Brian& Yorek, Mark A.. Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin : Effect on Vascular and Neural Complications. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-499913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499913