Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma
Joint Authors
Tong, Guo-Xia
Su, Gloria H.
Turk, Andrew T.
Close, Lanny G.
Caruana, Salvatore M.
Qiu, Wanglong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Salivary duct carcinoma (SDC) is an aggressive malignant tumor with a high mortality, which resembles high-grade breast ductal carcinoma in morphology.
The parotid gland is the most common location.
Its molecular genetic characteristics remain largely unknown.
We have previously reported high incidence of PIK3CA somatic mutations in head and neck squamous cell carcinoma, particularly in pharyngeal cancers.
Here we examined the PIK3CA gene expression status and hotspot mutations in six cases of SDC by immunohistochemistry and genomic DNA sequencing.
Immunohistochemistry showed that PIK3CA expression was elevated in all six patients with SDC.
By DNA sequencing, two hotspot mutations of the PIK3CA gene, E545K (exon 9) and H1047R (exon 20), were identified in two of the six cases.
Our results support that oncogenic PIK3CA is upregulated and frequently mutated in human SDC, adding evidence that PIK3CA oncogenic pathway is critical in the tumorigenesis of SDC, and may be a plausible drug target for this rare disease.
American Psychological Association (APA)
Qiu, Wanglong& Tong, Guo-Xia& Turk, Andrew T.& Close, Lanny G.& Caruana, Salvatore M.& Su, Gloria H.. 2014. Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499914
Modern Language Association (MLA)
Qiu, Wanglong…[et al.]. Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-499914
American Medical Association (AMA)
Qiu, Wanglong& Tong, Guo-Xia& Turk, Andrew T.& Close, Lanny G.& Caruana, Salvatore M.& Su, Gloria H.. Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499914