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Renal Cell Carcinoma Associated with Xp11.2 TranslocationTFE3 Gene Fusion : A Rare Case Report with Review of the Literature
Joint Authors
Nair, Balagopal
Ahluwalia, Puneet
Kumar, Ginil
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
The recently recognized renal cell carcinomas associated with Xp11.2 translocations are rare tumors predominantly reported in children.
Chromosome Xp11.2 translocation results in gene fusion related to transcription factor E3 (TFE3) that plays an important role in proliferation and survival.
Case Report.
Herein, we present two cases of a TFE3 translocation-associated RCC in young female adults, one detected incidentally and the other one presenting with gross hematuria.
Tumor is characterized by immunohistochemistry and a literature review with optimal treatment regimen is presented.
Discussion.
Xp11.2 translocation RCCs in adult patients are associated with advanced stages, large tumors, and extracapsular disease and usually have an aggressive clinical course.
Conclusion.
In TFE3 RCC, the genetic background may not only contribute to tumorigenesis, but also determine the response to chemotherapy and targeted therapy.
Therefore it is necessary to diagnose this tumor entity accurately.
Because of the small number of TFE3 gene fusion-related renal tumors described in the literature, the exact biologic behavior and impact of current treatment modalities remain to be uncertain.
American Psychological Association (APA)
Ahluwalia, Puneet& Nair, Balagopal& Kumar, Ginil. 2013. Renal Cell Carcinoma Associated with Xp11.2 TranslocationTFE3 Gene Fusion : A Rare Case Report with Review of the Literature. Case Reports in Urology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-499925
Modern Language Association (MLA)
Ahluwalia, Puneet…[et al.]. Renal Cell Carcinoma Associated with Xp11.2 TranslocationTFE3 Gene Fusion : A Rare Case Report with Review of the Literature. Case Reports in Urology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-499925
American Medical Association (AMA)
Ahluwalia, Puneet& Nair, Balagopal& Kumar, Ginil. Renal Cell Carcinoma Associated with Xp11.2 TranslocationTFE3 Gene Fusion : A Rare Case Report with Review of the Literature. Case Reports in Urology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-499925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499925