Mitochondria and PGC-1α in Aging and Age-Associated Diseases
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders.
While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders.
Recent studies indicate that maintenance of mitochondrial function is beneficial in the prevention or delay of age-associated diseases.
A central molecule seems to be the peroxisome proliferator-activated receptor γ coactivator α (PGC-1α), which is the key regulator of mitochondrial biogenesis.
Besides regulating mitochondrial function, PGC-1α targets several other cellular processes and thereby influences cell fate on multiple levels.
This paper discusses how mitochondrial function and PGC-1α are affected in age-associated diseases and how modulation of PGC-1α might offer a therapeutic potential for age-related pathology.
American Psychological Association (APA)
Wenz, Tina. 2011. Mitochondria and PGC-1α in Aging and Age-Associated Diseases. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-499930
Modern Language Association (MLA)
Wenz, Tina. Mitochondria and PGC-1α in Aging and Age-Associated Diseases. Journal of Aging Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-499930
American Medical Association (AMA)
Wenz, Tina. Mitochondria and PGC-1α in Aging and Age-Associated Diseases. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-499930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499930