Changing Patterns in the Clinical Pathological Features of Hodgkin Lymphoma : A Report from Debrecen, Hungary
Joint Authors
Miltényi, Zsófia
Gergely, Lajos
Váróczy, László
Simon, Zsófia
Páyer, Edit
Illés, Árpád
Jóna, Ádám
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Hodgkin lymphoma shows a well-known geographic pattern, but temporal changes have been found recently as well.
Patients and Methods.
439 Hodgkin lymphoma patients' clinicopathological and treatment data were processed in calendar periods of approximately ten years.
The patients were treated at our department from 1980 until the end of 2008.
Results.
The first period (1980–89) contained 177 patients, the second (1990–99) 147, and the third (2000–08) 115 Hodgkin lymphoma patients.
The mean age of the patients was 40.1, 35.9, and 36.8 years in order.
The male/female ratio: 1.42, 1.45, 1.05 in order.
Contrary-wise a unimodal age group pattern could have been seen with an incidence peak between 30 and 39 in the past decades.
The incidence of classical mixed cellularity histological subtype is decreasing (43.7%, 58.23%, 42.6%, P=0.0098 (it is only significant in the second period)); classical nodular sclerosis shows an increasing tendency (25%, 27.32%, 34.78%, P=0.1734).
The first incidence peak is predominantly created by classical nodular sclerosis, meanwhile the second peak by classical mixed cellularity.
The number of early-stage patients (59.12%) is beyond the advanced stage (40%) in the last decade.
Meanwhile, the number of second-stage patients was increasing (25.8%, 26.35%, 49.56% P<0.0001) and of patients in third stage was decreasing (53.4 %, 50.67%, 20% P<0.0001).
The 5- and 10-year overall survival data were progressing: 59.7 %, 77.4 %, and 90.5 % and 44.1 %, 70.6 % and 90.5 % (expected survival) in the last decade.
Conclusions.
Changes can be explained by the altered nature of Hodgkin lymphoma, the changes in socioeconomic status and the development of diagnostic and therapy methods.
American Psychological Association (APA)
Miltényi, Zsófia& Simon, Zsófia& Páyer, Edit& Váróczy, László& Gergely, Lajos& Jóna, Ádám…[et al.]. 2011. Changing Patterns in the Clinical Pathological Features of Hodgkin Lymphoma : A Report from Debrecen, Hungary. ISRN Hematology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-499945
Modern Language Association (MLA)
Miltényi, Zsófia…[et al.]. Changing Patterns in the Clinical Pathological Features of Hodgkin Lymphoma : A Report from Debrecen, Hungary. ISRN Hematology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-499945
American Medical Association (AMA)
Miltényi, Zsófia& Simon, Zsófia& Páyer, Edit& Váróczy, László& Gergely, Lajos& Jóna, Ádám…[et al.]. Changing Patterns in the Clinical Pathological Features of Hodgkin Lymphoma : A Report from Debrecen, Hungary. ISRN Hematology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-499945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499945