Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients : A Pilot Study

Abstract EN

Aim.

We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose.

Methods.

A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients.

Patients received sitagliptin or placebo after surgery for 4 days.

The primary endpoint was to estimate the effect of adjunctive sitagliptin versus placebo on overall mean blood glucose in the 4-day period after surgery.

Results.

Sixty-two patients participated.

Repeated measures tests indicated no significant difference between the groups in the overall mean blood glucose level with a mean of 147.2±4.8 mg/dL and 153.0±4.6 mg/dL for the test and the control group, respectively (P=0.388).

Conclusions.

Sitagliptin added to normal postoperative glucose management practices did not improve overall mean blood glucose control in diabetic patients in the postoperative setting.