Pulse Width Modulation Electro-Acupuncture on Cardiovascular Remodeling and Plasma Nitric Oxide in Spontaneously Hypertensive Rats
Joint Authors
Chen, Zhong-Ben
Feng, Qiu-Chao
You, Chao
Wang, Le-Xin
Xiong, Xuan
Yin, Ting
Ball, Patrick
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study was designed to investigate the effect of pulse width modulation electro-acupuncture (PWM-EA) on cardiovascular remodeling and nitric oxide (NO) in spontaneously hypertensive rats (SHR).
Thirty-four male SHR were randomly divided into control, captopril, and two PWM-EA groups, which were treated with 350 Hz (SHR-350 Hz) and whole audio bandwith electro-acupuncture (SHR-WAB group) respectively, on the ST 36 point located on the outside of the hind leg.
Systolic blood pressure (BP), plasma and myocardial NO were measured.
Histological studies were also performed on the aortic wall and the left ventricle.
The BP in the SHR-350 Hz, SHR-WAB and the captopril groups was lower than in the control group following the treatment (P < .05).
The average aortic media wall thickness in the two electro-acupuncture groups was less than in the control group (P < .05).
The left ventricle/heart weight ratio in the captopril and SHR-350 Hz groups was less than in the control group (P < .01), but was similar between the SHR-WAB and the control group (P > .05).
The plasma and myocardium NO levels were elevated in the captopril and the SHR-350 Hz group (P < .05 and .01, resp.).
The plasma level of NO in the SHR-WAB group was also higher than in the control group (P < .05).
We concluded that pulse width modulation electro-acupuncture on the ST 36 point prevents the progression of hypertension and diminishes the cardiovascular remodeling in SHR.
It also elevates plasma and cardiac NO in this animal model.
American Psychological Association (APA)
Xiong, Xuan& You, Chao& Feng, Qiu-Chao& Yin, Ting& Chen, Zhong-Ben& Ball, Patrick…[et al.]. 2011. Pulse Width Modulation Electro-Acupuncture on Cardiovascular Remodeling and Plasma Nitric Oxide in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499998
Modern Language Association (MLA)
Xiong, Xuan…[et al.]. Pulse Width Modulation Electro-Acupuncture on Cardiovascular Remodeling and Plasma Nitric Oxide in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499998
American Medical Association (AMA)
Xiong, Xuan& You, Chao& Feng, Qiu-Chao& Yin, Ting& Chen, Zhong-Ben& Ball, Patrick…[et al.]. Pulse Width Modulation Electro-Acupuncture on Cardiovascular Remodeling and Plasma Nitric Oxide in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499998