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Sustained High Level of Serum VEGF at Convalescent Stage Contributes to the Renal Recovery after HTNV Infection in Patients with Hemorrhagic Fever with Renal Syndrome
Joint Authors
Zhang, Yusi
Zhou, Xingchun
Zhang, Yun
Jin, Boquan
Wang, Jiuping
Ma, Ying
Yang, Angang
Yuan, Bin
Xu, Zhuwei
Zhang, Chunmei
Zhuang, Ran
Liu, Bei
Yu, Haitao
Yi, Jing
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To investigate the role of vascular endothelial growth factor (VEGF) in the increased permeability of vascular endothelial cells after Hantaan virus (HTNV) infection in humans, the concentration of VEGF in serum from HTNV infected patients was quantified with sandwich ELISA.
Generally, the level of serum VEGF in patients was elevated to 607.0 (542.2–671.9) pg/mL, which was dramatically higher compared with healthy controls (P<0.001).
There was a rapid increase of the serum VEGF level in all patients from the fever onset to oliguric stage, at which the serum creatinine reached the peak level of the disease, indicating that VEGF may be involved in the pathogenesis of renal hyper-permeability.
Moreover, the serum VEGF level at convalescent stage was positively correlated with the degree of the disease severity.
The sustained high level of serum VEGF at convalescence was observed in critical HFRS patients, suggesting that VEGF would probably contribute to the renal recovery after the virus clearance.
Taken together, our results suggested that the VEGF would be involved in the pathogenesis of renal dysfunction at the oliguric stage after HTNV infection, but may function as a recovery factor during the convalescence to help the body self-repair of the renal injury.
American Psychological Association (APA)
Ma, Ying& Liu, Bei& Yuan, Bin& Wang, Jiuping& Yu, Haitao& Zhang, Yun…[et al.]. 2012. Sustained High Level of Serum VEGF at Convalescent Stage Contributes to the Renal Recovery after HTNV Infection in Patients with Hemorrhagic Fever with Renal Syndrome. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-500017
Modern Language Association (MLA)
Ma, Ying…[et al.]. Sustained High Level of Serum VEGF at Convalescent Stage Contributes to the Renal Recovery after HTNV Infection in Patients with Hemorrhagic Fever with Renal Syndrome. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-500017
American Medical Association (AMA)
Ma, Ying& Liu, Bei& Yuan, Bin& Wang, Jiuping& Yu, Haitao& Zhang, Yun…[et al.]. Sustained High Level of Serum VEGF at Convalescent Stage Contributes to the Renal Recovery after HTNV Infection in Patients with Hemorrhagic Fever with Renal Syndrome. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-500017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500017