Intranasal, siRNA Delivery to the Brain by TATMGF Tagged PEGylated Chitosan Nanoparticles
Joint Authors
Malhotra, Meenakshi
Tomaro-Duchesneau, Catherine
Prakash, Satya
Saha, Shyamali
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
Neurodegeneration is characterized by progressive loss of structure and function of neurons.
Several therapeutic methods and drugs are available to alleviate the symptoms of these diseases.
The currently used delivery strategies such as implantation of catheters, intracarotid infusions, surgeries, and chemotherapies are invasive in nature and pose a greater risk of postsurgical complications, which can have fatal side effects.
The current study utilizes a peptide (TAT and MGF) tagged PEGylated chitosan nanoparticle formulation for siRNA delivery, administered intranasally, which can bypass the blood brain barrier.
The study investigates the optimal dose, duration, biodistribution, and toxicity, of the nanoparticle-siRNA formulation, in-vivo.
The results indicate that 0.5 mg/kg of siRNA is delivered successfully to the hippocampus, thalamus, hypothalamus, and Purkinje cells in the cerebellum after 4 hrs of post intranasal delivery.
The results indicate maximum delivery to the brain in comparison to other tissues with no cellular toxic effects.
This study shows the potential of peptide-tagged PEGylated chitosan nanoparticles to be delivered intranasally and target brain tissue for the treatment of neurological disorders.
American Psychological Association (APA)
Malhotra, Meenakshi& Tomaro-Duchesneau, Catherine& Saha, Shyamali& Prakash, Satya. 2013. Intranasal, siRNA Delivery to the Brain by TATMGF Tagged PEGylated Chitosan Nanoparticles. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500018
Modern Language Association (MLA)
Malhotra, Meenakshi…[et al.]. Intranasal, siRNA Delivery to the Brain by TATMGF Tagged PEGylated Chitosan Nanoparticles. Journal of Pharmaceutics No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-500018
American Medical Association (AMA)
Malhotra, Meenakshi& Tomaro-Duchesneau, Catherine& Saha, Shyamali& Prakash, Satya. Intranasal, siRNA Delivery to the Brain by TATMGF Tagged PEGylated Chitosan Nanoparticles. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500018