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A Review of ERCC1 Gene in Bladder Cancer : Implications for Carcinogenesis and Resistance to Chemoradiotherapy
Joint Authors
Kawashima, Atsunari
Tsujimura, Akira
Takayama, Hitoshi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The excision repair cross-complementing group 1 (ERCC1) gene performs a critical incision step in DNA repair and is reported to be correlated with carcinogenesis and resistance to drug or ionizing radiation therapy.
We reviewed the correlation between ERCC1 and bladder cancer.
In carcinogenesis, several reports discussed the relation between ERCC1 single nucleotide polymorphisms and carcinogenesis in bladder cancer only in case-control studies.
Regarding the relation between ERCC1 and resistance to chemoradiotherapy, in vitro and clinical studies indicate that ERCC1 might be related to resistance to radiation therapy rather than cisplatin therapy.
It is controversial whether ERCC1 predicts prognosis of bladder cancer treated with cisplatin-based chemotherapy.
Tyrosine kinase receptors or endothelial-mesenchymal transition are reported to regulate the expression of ERCC1, and further study is needed to clarify the mechanism of ERCC1 expression and resistance to chemoradiotherapy in vitro and to discover novel therapies for advanced and metastatic bladder cancer.
American Psychological Association (APA)
Kawashima, Atsunari& Takayama, Hitoshi& Tsujimura, Akira. 2011. A Review of ERCC1 Gene in Bladder Cancer : Implications for Carcinogenesis and Resistance to Chemoradiotherapy. Advances in Urology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500019
Modern Language Association (MLA)
Kawashima, Atsunari…[et al.]. A Review of ERCC1 Gene in Bladder Cancer : Implications for Carcinogenesis and Resistance to Chemoradiotherapy. Advances in Urology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-500019
American Medical Association (AMA)
Kawashima, Atsunari& Takayama, Hitoshi& Tsujimura, Akira. A Review of ERCC1 Gene in Bladder Cancer : Implications for Carcinogenesis and Resistance to Chemoradiotherapy. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500019