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The Dynamic Structure of the Estrogen Receptor
Joint Authors
Jasuja, Ravi
Miki, Rika
Bhasin, Shalender
Singh, Rajan
Kumar, Raj
Zakharov, Mikhail N.
Toraldo, Gianluca
Jang, Hyeran
Khan, Shagufta H.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The estrogen receptor (ER) mediates most of the biological effects of estrogens at the level of gene regulation by interacting through its site-specific DNA and with other coregulatory proteins.
In recent years, new information regarding the dynamic structural nature of ER has emerged.
The physiological effects of estrogen are manifested through ER's two isoforms, ERα and ERβ.
These two isoforms (ERα and ERβ) display distinct regions of sequence homology.
The three-dimensional structures of the DNA-binding domain (DBD) and ligand-binding domain (LBD) have been solved, whereas no three-dimensional natively folded structure for the ER N-terminal domain (NTD) is available to date.
However, insights about the structural and functional correlations regarding the ER NTD have recently emerged.
In this paper, we discuss the knowledge about the structural characteristics of the ER in general and how the structural features of the two isoforms differ, and its subsequent role in gene regulation.
American Psychological Association (APA)
Kumar, Raj& Zakharov, Mikhail N.& Khan, Shagufta H.& Miki, Rika& Jang, Hyeran& Toraldo, Gianluca…[et al.]. 2011. The Dynamic Structure of the Estrogen Receptor. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-500032
Modern Language Association (MLA)
Kumar, Raj…[et al.]. The Dynamic Structure of the Estrogen Receptor. Journal of Amino Acids No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-500032
American Medical Association (AMA)
Kumar, Raj& Zakharov, Mikhail N.& Khan, Shagufta H.& Miki, Rika& Jang, Hyeran& Toraldo, Gianluca…[et al.]. The Dynamic Structure of the Estrogen Receptor. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-500032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500032