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Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib
Joint Authors
Kotani, Yoshikazu
Hatakeyama, Yukihisa
Tamura, Daisuke
Kasai, Daisuke
Hori, Suya
Kobayashi, Kazuyuki
Funada, Yasuhiro
Katsurada, Masahiro
Nagano, Tatsuya
Nishimura, Yoshihiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 73-year-old Japanese man was histologically diagnosed with lung adenocarcinoma harboring an exon 19 deletion in the epidermal growth factor receptor.
The patient was treated with gefitinib for 6 weeks until he developed substantially elevated hepatic enzyme levels that resulted in the discontinuation of gefitinib.
Gefitinib was reintroduced with an intermittent treatment schedule after the transaminase levels normalized, but the patient's enzyme levels rose again, and the cancer progressed.
Gefitinib was eventually replaced with erlotinib.
There was stable disease for 7 weeks without any signs of liver toxicity.
Thus, erlotinib may be a beneficial and well-tolerated treatment option for patients with gefitinib-related hepatotoxicity.
American Psychological Association (APA)
Nagano, Tatsuya& Kotani, Yoshikazu& Kobayashi, Kazuyuki& Katsurada, Masahiro& Hatakeyama, Yukihisa& Hori, Suya…[et al.]. 2011. Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib. Case Reports in Pulmonology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-500069
Modern Language Association (MLA)
Nagano, Tatsuya…[et al.]. Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib. Case Reports in Pulmonology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-500069
American Medical Association (AMA)
Nagano, Tatsuya& Kotani, Yoshikazu& Kobayashi, Kazuyuki& Katsurada, Masahiro& Hatakeyama, Yukihisa& Hori, Suya…[et al.]. Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib. Case Reports in Pulmonology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-500069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500069