CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI
Joint Authors
Ristagno, Angelique
Kyriakides, Zenon S.
Boulanger, Chantal M.
McGregor, John L.
Fraser, Paul
McGregor, Lilian
Bultelle, Florence
Collot-Teixeira, Sophie
Leseche, Guy
Poston, Robin N.
Koutouzis, Michael
Barbatis, Calypso
Pasterkamp, Gerard
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
OxLDL uptake and cholesterol efflux inhibition in macrophages play a key role in atherosclerotic plaque formation, rupture, and thrombotic ischemia.
This study investigates genes implicated in OxLDL uptake (CD36, SRA), cholesterol efflux inhibition (adipophilin, ADFP), and inflammatory recruitments of leukocytes (IL-8) in plaque lesion areas (PLAs) compared to nonplaque lesion areas (NPLAs) in human carotid endarterectomy specimens.
Gene and protein expressions were assayed using quantitative PCR and quantitative immunohistochemistry.
Pearson tests were used to investigate potential correlation between (a) different gene expressions and (b) gene expression and patient's plasma constituents.
CD36, SRA, ADFP, and IL-8 were shown to be significantly more expressed in PLA compared to NPLA.
In PLA, a significant correlation was observed between CD36, SRA, ADFP, and IL-8 mRNA levels.
Moreover, CD36 expression level was significantly inversely correlated to plasma marker ApoAI.
The above investigated genes/proteins may play a key role in the maturation of atherosclerotic lesions.
American Psychological Association (APA)
Collot-Teixeira, Sophie& Barbatis, Calypso& Bultelle, Florence& Koutouzis, Michael& Pasterkamp, Gerard& Fraser, Paul…[et al.]. 2008. CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-500092
Modern Language Association (MLA)
Collot-Teixeira, Sophie…[et al.]. CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-500092
American Medical Association (AMA)
Collot-Teixeira, Sophie& Barbatis, Calypso& Bultelle, Florence& Koutouzis, Michael& Pasterkamp, Gerard& Fraser, Paul…[et al.]. CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-500092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500092