CD8+CXCR5+ T Cells Regulate Pathology in the Genital Tract
Joint Authors
Wei, Bo
Liu, Guangchao
Champion, Cheryl I.
Jiang, Janina
Kelly, Kathleen A.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We have identified a CD8+CXCR5+ T cell that prevents the development of oviduct dilation following C.
muridarum genital infection.
Phenotypic studies show that CD8+CXCR5+ cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin).
Cxcr5-/- mice have significantly lower numbers of CD8+ cells and lack the CD8+CXCR5+ population while the total number of CD4+ cells is equivalent between mouse strains.
The transfer of CD8+ splenocytes from WT mice reduces the oviduct dilation seen in Cxcr5-/- mice following C.
muridarum infection.
Future studies will investigate the mechanism by which this cell type regulates genital tract pathology.
American Psychological Association (APA)
Jiang, Janina& Champion, Cheryl I.& Wei, Bo& Liu, Guangchao& Kelly, Kathleen A.. 2013. CD8+CXCR5+ T Cells Regulate Pathology in the Genital Tract. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-500093
Modern Language Association (MLA)
Jiang, Janina…[et al.]. CD8+CXCR5+ T Cells Regulate Pathology in the Genital Tract. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-500093
American Medical Association (AMA)
Jiang, Janina& Champion, Cheryl I.& Wei, Bo& Liu, Guangchao& Kelly, Kathleen A.. CD8+CXCR5+ T Cells Regulate Pathology in the Genital Tract. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-500093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500093