Tongxinluo Improves Cardiac Function and Ameliorates Ventricular Remodeling in Mice Model of Myocardial Infarction through Enhancing Angiogenesis
Joint Authors
Xing, Yi-Fan
Liu, Xiao-Qiong
Zhao, Yu-Xia
Lu, Xiao-Ting
Wang, Bo
Guo, Tao
Sun, Yuan-Yuan
Bai, Wen-Wu
Wang, Ying-Bin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Myocardial infarction (MI) is a major cause of morbidity and mortality in the world.
Tongxinluo (TXL) is a traditional Chinese compound prescription which has cardioprotective functions.
The present study was aimed to determine the effect of TXL on postischemic cardiac dysfunction and cardiac remodeling and to elucidate the underlying mechanisms.
Methods and Results.
MI was performed by ligation of left anterior descending coronary artery (LAD) in male adult mice.
Mice were randomly divided into four groups: (1) sham group (Sham); (2) MI-control group (Control); (3) MI-low dose TXL group (TXL-L); and (4) MI-high dose TXL (TXL-H) group.
Compared with the control group, TXL treatment restored cardiac function, increased revascularization, attenuated cardiomyocyte apoptosis, and reduced interstitial fibrosis.
TXL treatment increased the phosphorylation of Akt, extracellular signal regulated kinase (ERK), and endothelial nitric oxide synthase (eNOS); the expression of phosphatidylinositol3-kinase (PI3K), hypoxia-inducible factors 1α (HIF-1α), and vascular endothelial growth factor (VEGF); and the DNA binding activity of HIF-1α after MI.
Conclusion.
TXL may improve cardiac function and ameliorate cardiac remodeling by increasing neovascularization through enhancing the phosphorylation of Akt and ERK, the expression and activity of HIF-1α, and the protein level of VEGF and p-eNOS.
American Psychological Association (APA)
Bai, Wen-Wu& Xing, Yi-Fan& Wang, Bo& Lu, Xiao-Ting& Wang, Ying-Bin& Sun, Yuan-Yuan…[et al.]. 2013. Tongxinluo Improves Cardiac Function and Ameliorates Ventricular Remodeling in Mice Model of Myocardial Infarction through Enhancing Angiogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-500094
Modern Language Association (MLA)
Bai, Wen-Wu…[et al.]. Tongxinluo Improves Cardiac Function and Ameliorates Ventricular Remodeling in Mice Model of Myocardial Infarction through Enhancing Angiogenesis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-500094
American Medical Association (AMA)
Bai, Wen-Wu& Xing, Yi-Fan& Wang, Bo& Lu, Xiao-Ting& Wang, Ying-Bin& Sun, Yuan-Yuan…[et al.]. Tongxinluo Improves Cardiac Function and Ameliorates Ventricular Remodeling in Mice Model of Myocardial Infarction through Enhancing Angiogenesis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-500094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500094