MoMuLV-ts-1 : A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk
Joint Authors
Bagalb, H.
Okonta, H.
Duggan, J.
Chakraborty, J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Our laboratory has developed a murine model of lymphoma via breast milk transmission of MoMuLV-ts-1 (Moloney murine leukemia virus-temperature sensitive mutant-1).
Uninfected offspring suckled from infected surrogate mothers become infected and develop lymphoma.
Multiple gene integration sites of ts-1 into the infected mouse genome including tacc3, aurka, ndel1, tpx2, p53, and rhamm were identified, and mRNA expressions were quantitated.
These genes produce centrosomal proteins, which may be involved in abnormal chromosomal segregation leading to aneuploidy or multiploidy, thus causing lymphoma.
Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis.
American Psychological Association (APA)
Chakraborty, J.& Okonta, H.& Bagalb, H.& Duggan, J.. 2011. MoMuLV-ts-1 : A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk. Advances in Virology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-500132
Modern Language Association (MLA)
Chakraborty, J.…[et al.]. MoMuLV-ts-1 : A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk. Advances in Virology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-500132
American Medical Association (AMA)
Chakraborty, J.& Okonta, H.& Bagalb, H.& Duggan, J.. MoMuLV-ts-1 : A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-500132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500132