![](/images/graphics-bg.png)
Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model
Joint Authors
Lin, Ching-Chung
Tsai, Shu-Jung
Chen, Ming-Jen
Liu, Chia-Yuan
Shih, Shou-Chuan
Chen, Yu-Jen
Wang, Horng-Yuan
Wang, Tsang-En
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Peritoneal carcinomatosis (PC) accompanied with ascites formation causes several distressing symptoms, resulting in poor quality of life.
Methods.
Twenty BALB/c nude mice generated by direct orthotopic injection of human pancreatic cancer PANC-1 cells were randomized to receive either a stock laboratory diet or a stock diet supplemented with glutamine.
Half of the mice were sacrificed at day 76 to measure the amount of ascitic fluid and pancreatic tumor volume.
The remaining mice were subject to survival analysis.
Serum albumin levels were estimated every 2 weeks.
Results.
At day 76, the average amount of ascitic fluid measured in the control group was 1.2±0.3 mL compared to 0.5±0.5 mL from the glutamine-supplemented mice (P=0.045).
The volume of pancreatic tumor was 2.60±0.8 cm3 in the control group and 1.98±1.3 cm3 in glutamine-supplemented mice (P=0.39).
The mean survival time of glutamine-supplemented mice was prolonged from 87±4 to 101±2 days (P=0.0024).
Mean serum albumin levels were higher in the glutamine-supplemented group.
Conclusions.
This preclinical study showed that oral supplementation of glutamine may provide ascites-reducing activity in pancreatic cancer patients with PC, via a cell-mediated immunity-independent mechanism.
American Psychological Association (APA)
Chen, Ming-Jen& Wang, Tsang-En& Tsai, Shu-Jung& Lin, Ching-Chung& Liu, Chia-Yuan& Wang, Horng-Yuan…[et al.]. 2013. Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500165
Modern Language Association (MLA)
Chen, Ming-Jen…[et al.]. Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model. Gastroenterology Research and Practice No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-500165
American Medical Association (AMA)
Chen, Ming-Jen& Wang, Tsang-En& Tsai, Shu-Jung& Lin, Ching-Chung& Liu, Chia-Yuan& Wang, Horng-Yuan…[et al.]. Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500165