NGcGM3 Ganglioside : A Privileged Target for Cancer Vaccines
Joint Authors
Fainboim, Leonardo
Guthmann, Marcelo D.
Fernandez, Luis E.
Alonso, Daniel F.
Gomez, Roberto E.
Gabri, Mariano R.
Gold, Silvia
Gomez, Daniel E.
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Active specific immunotherapy is a promising field in cancer research.
N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy.
Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer.
The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products.
A brief discussion on the relevance of prioritization of cancer antigens in vaccine development is also included.
American Psychological Association (APA)
Fernandez, Luis E.& Gabri, Mariano R.& Guthmann, Marcelo D.& Gomez, Roberto E.& Gold, Silvia& Fainboim, Leonardo…[et al.]. 2010. NGcGM3 Ganglioside : A Privileged Target for Cancer Vaccines. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-500209
Modern Language Association (MLA)
Fernandez, Luis E.…[et al.]. NGcGM3 Ganglioside : A Privileged Target for Cancer Vaccines. Clinical and Developmental Immunology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-500209
American Medical Association (AMA)
Fernandez, Luis E.& Gabri, Mariano R.& Guthmann, Marcelo D.& Gomez, Roberto E.& Gold, Silvia& Fainboim, Leonardo…[et al.]. NGcGM3 Ganglioside : A Privileged Target for Cancer Vaccines. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-500209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500209
