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Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats
Joint Authors
Hu, Yinming
Zhang, Hong-liang
Tao, Yi
Su, Zheng-quan
Gao, Bing
Guo, Jiao
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Chitosan, a deacetylated product of chitin, has been demonstrated to lower cholesterol in humans and animals.
However, chitosan is not fully soluble in water which would influence absorption in the human intestine.
In addition, water-soluble chitosan (WSC) has higher reactivity compared to chitosan.
The present study was designed to clarify the effects of WSC and water-soluble chitosan nanoparticles (WSC-NPs) on hypercholesterolemia induced by feeding a high-fat diet in male Sprague-Dawley rats.
WSC-NPs were prepared by the ionic gelation method and the spray-drying technique.
The nanoparticles were spherical in shape and had a smooth surface.
The mean size of WSC-NPs was 650 nm variing from 500 to 800 nm.
Results showed that WSC-NPs reduced the blood lipids and plasma viscosity significantly and increased the serum superoxide dismutase (SOD) activities significantly.
This paper is the first report of the lipid-lowering effects of WSC-NPs suggesting that the WSC-NPs could be used for the treatment of hypercholesterolemia.
American Psychological Association (APA)
Tao, Yi& Zhang, Hong-liang& Gao, Bing& Guo, Jiao& Hu, Yinming& Su, Zheng-quan. 2010. Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-500217
Modern Language Association (MLA)
Tao, Yi…[et al.]. Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats. Journal of Nanomaterials No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-500217
American Medical Association (AMA)
Tao, Yi& Zhang, Hong-liang& Gao, Bing& Guo, Jiao& Hu, Yinming& Su, Zheng-quan. Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats. Journal of Nanomaterials. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-500217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500217