Cancer Incidence and Mortality in a Cohort of US Blood Donors : A 20-Year Study
Joint Authors
Busch, Michael P.
Hirschler, Nora V.
Vahidnia, Farnaz
Chinn, Artina
Custer, Brian
Agapova, Maria
Source
Journal of Cancer Epidemiology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Blood donors are considered one of the healthiest populations.
This study describes the epidemiology of cancer in a cohort of blood donors up to 20 years after blood donation.
Records from donors who participated in the Retroviral Epidemiology Donor Study (REDS, 1991–2002) at Blood Centers of the Pacific (BCP), San Francisco, were linked to the California Cancer Registry (CCR, 1991–2010).
Standardized incidence ratios (SIR) were estimated using standard US 2000 population, and survival analysis used to compare all-cause mortality among donors and a random sample of nondonors with cancer from CCR.
Of 55,158 eligible allogeneic blood donors followed-up for 863,902 person-years, 4,236 (7.7%) primary malignant cancers were diagnosed.
SIR in donors was 1.59 (95% CI = 1.54,1.64).
Donors had significantly lower mortality (adjusted HR = 0.70, 95% CI = 0.66–0.74) compared with nondonor cancer patients, except for respiratory system cancers (adjusted HR = 0.93, 95% CI = 0.82–1.05).
Elevated cancer incidence among blood donors may reflect higher diagnosis rates due to health seeking behavior and cancer screening in donors.
A “healthy donor effect” on mortality following cancer diagnosis was demonstrated.
This population-based database and sample repository of blood donors with long-term monitoring of cancer incidence provides the opportunity for future analyses of genetic and other biomarkers of cancer.
American Psychological Association (APA)
Vahidnia, Farnaz& Hirschler, Nora V.& Agapova, Maria& Chinn, Artina& Busch, Michael P.& Custer, Brian. 2013. Cancer Incidence and Mortality in a Cohort of US Blood Donors : A 20-Year Study. Journal of Cancer Epidemiology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500245
Modern Language Association (MLA)
Vahidnia, Farnaz…[et al.]. Cancer Incidence and Mortality in a Cohort of US Blood Donors : A 20-Year Study. Journal of Cancer Epidemiology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-500245
American Medical Association (AMA)
Vahidnia, Farnaz& Hirschler, Nora V.& Agapova, Maria& Chinn, Artina& Busch, Michael P.& Custer, Brian. Cancer Incidence and Mortality in a Cohort of US Blood Donors : A 20-Year Study. Journal of Cancer Epidemiology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500245