Targeting Spleen Tyrosine Kinase-Bruton’s Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis
Joint Authors
Huang, Shyh-Jer
Cheng, Chao-Wen
Chen, Jin-Shuen
Chang, Li-Chien
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The importance of B-cell activation and immune complex-mediated Fc-receptor activation in the pathogenesis of immunologically mediated glomerulonephritis has long been recognized.
The two nonreceptor tyrosine kinases, spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (Btk), are primarily expressed by hematopoietic cells, and participate in B-cell-receptor- and Fc-receptor-mediated activation.
Pharmacological inhibitors of Syk or Btk are undergoing preclinical development and clinical trials for several immune diseases; and Syk inhibitors have been shown to reduce disease activity in rheumatoid arthritis patients.
However, the clinical therapeutic efficacies of these inhibitors in glomerulonephritis have not been evaluated.
Herein, we review recent studies of Syk and Btk inhibitors in several experimental primary and secondary glomerulonephritis models.
These inhibitors suppressed development of glomerular injury, and also ameliorated established kidney disease.
Thus, targeting Syk and Btk signaling pathways is a potential therapeutic strategy for glomerulonephritis, and further evaluation is recommended.
American Psychological Association (APA)
Chen, Jin-Shuen& Chang, Li-Chien& Huang, Shyh-Jer& Cheng, Chao-Wen. 2014. Targeting Spleen Tyrosine Kinase-Bruton’s Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-500248
Modern Language Association (MLA)
Chen, Jin-Shuen…[et al.]. Targeting Spleen Tyrosine Kinase-Bruton’s Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-500248
American Medical Association (AMA)
Chen, Jin-Shuen& Chang, Li-Chien& Huang, Shyh-Jer& Cheng, Chao-Wen. Targeting Spleen Tyrosine Kinase-Bruton’s Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-500248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500248