![](/images/graphics-bg.png)
PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds
Joint Authors
Nakajima, Yu
Ashibe, Bunichiro
Fukui, Yuka
Motojima, Kiyoto
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Plants contain potentially toxic compounds for animals and animals have developed physiological strategies to detoxify the ingested toxins during evolution.
Feeding mice with various plant seeds and grains showed unexpected result that only sesame killed PPARα-null mice but not wild-type mice at all.
A detailed analysis of this observation revealed that PPARα is involved in the metabolism of toxic compounds from plants as well as endobiotic substrates by inducing phase I and phase II detoxification enzymes.
PPARα plays a vital role in direct or indirect activation of the relevant genes via the complex network among other xenobiotic nuclear receptors.
Thus, PPARα plays its wider and more extensive role in energy metabolism from natural food intake to fat storage than previously thought.
American Psychological Association (APA)
Ashibe, Bunichiro& Nakajima, Yu& Fukui, Yuka& Motojima, Kiyoto. 2012. PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds. PPAR Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500256
Modern Language Association (MLA)
Ashibe, Bunichiro…[et al.]. PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds. PPAR Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-500256
American Medical Association (AMA)
Ashibe, Bunichiro& Nakajima, Yu& Fukui, Yuka& Motojima, Kiyoto. PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500256