Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues
Joint Authors
Yasmin, Sabina
Jadav, Surender Singh
Singh, Monika
Ahsan, Mohamed Jawed
Sharma, Jyotika
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues.
The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers cell lines.
N-(2,4-Dimethylphenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine (4s) showed maximum activity with mean growth percent (GP) of 62.61 and was found to be the most sensitive on MDA-MB-435 (melanoma), K-562 (leukemia), T-47D (breast cancer), and HCT-15 (colon cancer) cell lines with GP of 15.43, 18.22, 34.27, and 39.77, respectively.
Maximum GP was observed on MDA-MB-435 (melanoma) cell line (GP=6.82) by compound N-(2,4-dimethylphenyl)-5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-amine (4u).
American Psychological Association (APA)
Ahsan, Mohamed Jawed& Sharma, Jyotika& Singh, Monika& Jadav, Surender Singh& Yasmin, Sabina. 2014. Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500266
Modern Language Association (MLA)
Ahsan, Mohamed Jawed…[et al.]. Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-500266
American Medical Association (AMA)
Ahsan, Mohamed Jawed& Sharma, Jyotika& Singh, Monika& Jadav, Surender Singh& Yasmin, Sabina. Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500266