Proteomic Profiling of Thyroid Papillary Carcinoma
Joint Authors
Ban, Yoshiyuki
Akasu, Haruki
Tachikawa, Tetsuhiko
Bando, Yasuhiko
Igarashi, Takehito
Yamamoto, Gou
Hirano, Tsutomu
Hayashi, Shigeo
Ban, Yoshio
Shimizu, Kazuo
Takada, Michiya
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy.
We performed shotgun liquid chromatography (LC)/tandem mass spectrometry (MS/MS) analysis on pooled protein extracts from patients with PTC and compared the results with those from normal thyroid tissue validated by real-time (RT) PCR and immunohistochemistry (IHC).
We detected 524 types of protein in PTC and 432 in normal thyroid gland.
Among these proteins, 145 were specific to PTC and 53 were specific to normal thyroid gland.
We have also identified two important new markers, nephronectin (NPNT) and malectin (MLEC).
Reproducibility was confirmed with several known markers, but the one of two new candidate markers such as MLEC did not show large variations in expression levels.
Furthermore, IHC confirmed the overexpression of both those markers in PTCs compared with normal surrounding tissues.
Our protein data suggest that NPNT and MLEC could be a characteristic marker for PTC.
American Psychological Association (APA)
Ban, Yoshiyuki& Yamamoto, Gou& Takada, Michiya& Hayashi, Shigeo& Ban, Yoshio& Shimizu, Kazuo…[et al.]. 2012. Proteomic Profiling of Thyroid Papillary Carcinoma. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500277
Modern Language Association (MLA)
Ban, Yoshiyuki…[et al.]. Proteomic Profiling of Thyroid Papillary Carcinoma. Journal of Thyroid Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-500277
American Medical Association (AMA)
Ban, Yoshiyuki& Yamamoto, Gou& Takada, Michiya& Hayashi, Shigeo& Ban, Yoshio& Shimizu, Kazuo…[et al.]. Proteomic Profiling of Thyroid Papillary Carcinoma. Journal of Thyroid Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500277