Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy
Joint Authors
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors.
This is, however, a double-edged sword with many adverse effects.
Since the liver has a rich blood supply and plays an active role in the metabolism of medications, it is not surprising that there can be hepatic injury related to chemotherapy.
In addition, radioembolization may affect the parenchyma of normal and cirrhotic livers.
We review chemotherapy-associated liver injury in patients with colorectal liver metastases, including downsizing chemotherapy and neoadjuvant chemotherapy.
We discuss the mechanism of the hepatic injury, secondary to reactive oxygen species, and the spectrum of hepatic injury including, steatosis, steatohepatitis, hepatic sinusoidal injury and highlight the pharmacogenomics of such liver insults.
Methods for reducing and treating the hepatotoxicity are discussed for specific agents including tamxifen and the newly introduced targeted antibodies.
American Psychological Association (APA)
Maor, Y.& Malnick, S.. 2013. Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-500279
Modern Language Association (MLA)
Maor, Y.& Malnick, S.. Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-500279
American Medical Association (AMA)
Maor, Y.& Malnick, S.. Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-500279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500279