Physeal Bystander Effects in Rhabdomyosarcoma Radiotherapy : Experiments in a New Xenograft Model
Joint Authors
Horton, Jason A.
Strauss, Judith A.
Allen, Matthew J.
Damron, Timothy A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Radiotherapy used in the treatment of pediatric musculoskeletal sarcomas may result in crippling defects of skeletal growth.
Several radioprotective strategies have shown potential for preserving function of the irradiated epiphysis but have not been evaluated in a tumor-bearing animal model.
We developed two bioluminescent human rhabdomyosarcoma cell lines that were used to establish xenograft tumors in skeletally immature mice.
Bioluminescence imaging and radiography allowed serial evaluation of tumor growth and tibial elongation following localized radiotherapy.
High-dose (10 Gy) radiotherapy significantly reduced tumor growth velocity and prolonged the median survival of tumor-bearing mice but also resulted in a significant 3.3% shortening of the irradiated limb.
Exposure to a lower, 2 Gy dose resulted in 4.1% decrease in limb length but did not extend survival.
This new model provides a clinically relevant means to test the efficacy and safety of novel radioprotectant and radiorecovery strategies for use in this context.
American Psychological Association (APA)
Horton, Jason A.& Strauss, Judith A.& Allen, Matthew J.& Damron, Timothy A.. 2011. Physeal Bystander Effects in Rhabdomyosarcoma Radiotherapy : Experiments in a New Xenograft Model. Sarcoma،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-500286
Modern Language Association (MLA)
Horton, Jason A.…[et al.]. Physeal Bystander Effects in Rhabdomyosarcoma Radiotherapy : Experiments in a New Xenograft Model. Sarcoma No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-500286
American Medical Association (AMA)
Horton, Jason A.& Strauss, Judith A.& Allen, Matthew J.& Damron, Timothy A.. Physeal Bystander Effects in Rhabdomyosarcoma Radiotherapy : Experiments in a New Xenograft Model. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-500286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500286