IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with PolymyositisDermatomyositis
Joint Authors
Katsumata, Yasuhiro
Kataoka, Sayuri
Gono, Takahisa
Yamanaka, Hisashi
Kawasumi, Hidenaga
Kawaguchi, Yasushi
Hanaoka, Masanori
Kaneko, Hirotaka
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Hyperferritinemia is frequently accompanied by rapidly progressive (RP) interstitial lung disease (ILD) with polymyositis (PM)/dermatomyositis (DM).
To clarify the mechanism of RP-ILD with hyperferritinemia, we investigated the associations between serum ferritin levels and various cytokines in patients with PM/DM.
Methods.
This retrospective study included 38 patients admitted to our hospital with PM/DM.
Levels of serum ferritin and cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-18, TNF-α, IFN-α, IFN-γ, and IP-10) were measured.
Disease activity was evaluated using the tool proposed by the International Myositis Assessment and Clinical Studies Group.
We analyzed the associations between disease activity and levels of serum ferritin and cytokines.
Results.
The levels of serum ferritin, IL-8, IL-10, IL-18, and TNF-α, were significantly correlated with disease activity.
In a multivariate analysis, IL-6 (t=3.6,P=0.0010), IL-8 (t=4.8,P<0.0001), and IL-10 (t=5.7,P<0.0001) significantly contributed to serum ferritin levels.
The levels of serum ferritin, IL-6, IL-8, and IL-10, were higher in the RP-ILD subset than in the non-ILD subset or the chronic ILD subset.
Conclusion.
IL-6, IL-8, and IL-10 are significant contributors to hyperferritinemia in PM/DM.
The regulation of these cytokines might offer a possible treatment strategy for RP-ILD with PM/DM.
American Psychological Association (APA)
Kawasumi, Hidenaga& Gono, Takahisa& Kawaguchi, Yasushi& Kaneko, Hirotaka& Katsumata, Yasuhiro& Hanaoka, Masanori…[et al.]. 2014. IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with PolymyositisDermatomyositis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-500292
Modern Language Association (MLA)
Kawasumi, Hidenaga…[et al.]. IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with PolymyositisDermatomyositis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-500292
American Medical Association (AMA)
Kawasumi, Hidenaga& Gono, Takahisa& Kawaguchi, Yasushi& Kaneko, Hirotaka& Katsumata, Yasuhiro& Hanaoka, Masanori…[et al.]. IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with PolymyositisDermatomyositis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-500292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500292