Gefitinib in Non Small Cell Lung Cancer
Joint Authors
Bryce, Jane
Giordano, Pasqualina
Rocco, Gaetano
Di Maio, Massimo
Perrone, Francesco
Carillio, Guido
Costanzo, Raffaele
Piccirillo, Maria Carmela
Morabito, Alessandro
Daniele, Gennaro
Normanno, Nicola
Montanino, Agnese
De Feo, Gianfranco
Sandomenico, Claudia
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Gefitinib is an oral, reversible, tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) that plays a key role in the biology of non small cell lung cancer (NSCLC).
Phase I studies indicated that the recommended dose of gefitinib was 250 mg/day.
Rash, diarrhea, and nausea were the most common adverse events.
The positive results obtained in early phase 2 clinical trials with gefitinib were not confirmed in large phase 3 trials in unselected patients with advanced NSCLC.
The subsequent discovery that the presence of somatic mutations in the kinase domain of EGFR strongly correlates with increased responsiveness to EGFR tyrosine kinase inhibitors prompted phase 2 and 3 trials with gefitinib in the first line-treatment of EGFR-mutated NSCLC.
The results of these trials have demonstrated the efficacy of gefitinib that can be now considered as the standard first-line treatment of patients with advanced NSCLC harbouring activating EGFR mutations.
American Psychological Association (APA)
Costanzo, Raffaele& Piccirillo, Maria Carmela& Sandomenico, Claudia& Carillio, Guido& Montanino, Agnese& Daniele, Gennaro…[et al.]. 2011. Gefitinib in Non Small Cell Lung Cancer. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-500296
Modern Language Association (MLA)
Costanzo, Raffaele…[et al.]. Gefitinib in Non Small Cell Lung Cancer. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-500296
American Medical Association (AMA)
Costanzo, Raffaele& Piccirillo, Maria Carmela& Sandomenico, Claudia& Carillio, Guido& Montanino, Agnese& Daniele, Gennaro…[et al.]. Gefitinib in Non Small Cell Lung Cancer. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-500296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500296