Normal and Reversed-Phase HPTLC Methods for Simultaneous Estimation of Telmisartan and Metoprolol Succinate in Pharmaceutical Formulation
Joint Authors
Nawale, Prajakta S.
Patil, Amod S.
Shirkhedkar, Atul A.
Surana, Sanjay J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Two simple precise normal-phase (Method I) and reversed-phase (Method II) HPTLC/densitometry method have been developed for simultaneous determination of telmisartan and metoprolol succinate in bulk and in combined tablet formulation.
Method I was developed with aluminium plates precoated with silica gel 60F254S, and toluene : propanol : methanol : triethylamine (8 : 1 : 1 : 0.5 v/v) was used as as mobile phase.
Method II was carried out using aluminium coated with RP-18 silica gel 60 F254S HPTLC plates using methanol : water : triethylamine (6 : 4 : 0.5 v/v) as mobile phase.
Both analyses were scanned with a densitometer at 242 nm.
In Method I, good separation and resolution of drugs were achieved with Rf values 0.45±0.02 (telmisartan) and 0.70 ± 0.02 (metoprolol), while in Method II, telmisartan and metoprolol showed Rf values 0.55 ± 0.02 and 0.41± 0.02, respectively.
These methods can be used in routine pharmaceutical analysis.
American Psychological Association (APA)
Nawale, Prajakta S.& Shirkhedkar, Atul A.& Surana, Sanjay J.& Patil, Amod S.. 2011. Normal and Reversed-Phase HPTLC Methods for Simultaneous Estimation of Telmisartan and Metoprolol Succinate in Pharmaceutical Formulation. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500303
Modern Language Association (MLA)
Nawale, Prajakta S.…[et al.]. Normal and Reversed-Phase HPTLC Methods for Simultaneous Estimation of Telmisartan and Metoprolol Succinate in Pharmaceutical Formulation. ISRN Analytical Chemistry No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-500303
American Medical Association (AMA)
Nawale, Prajakta S.& Shirkhedkar, Atul A.& Surana, Sanjay J.& Patil, Amod S.. Normal and Reversed-Phase HPTLC Methods for Simultaneous Estimation of Telmisartan and Metoprolol Succinate in Pharmaceutical Formulation. ISRN Analytical Chemistry. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500303