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Medullary Thyroid Carcinoma : Molecular Signaling Pathways and Emerging Therapies
Joint Authors
Varghese, Jeena
Jiménez, Camilo
Gómez, Karen
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Research on medullary thyroid carcinoma (MTC) over the last 55 years has led to a good understanding of the genetic defects and altered molecular pathways associated with its development.
Currently, with the use of genetic testing, patients at high risk for MTC can be identified before the disease develops and offered prophylactic treatment.
In cases of localized neck disease, surgery can be curative.
However, once MTC has spread beyond the neck, systemic therapy may be necessary.
Conventional chemotherapy has been shown to be ineffective; however, multikinase inhibitors have shown promise in stabilizing disease, and this year will probably see the approval of a drug (Vandetanib) for advanced unresectable or metastatic disease, which represents a new chapter in the history of MTC.
In this paper, we explore newly understood molecular pathways and the most promising emerging therapies that may change the management of MTC.
American Psychological Association (APA)
Gómez, Karen& Varghese, Jeena& Jiménez, Camilo. 2011. Medullary Thyroid Carcinoma : Molecular Signaling Pathways and Emerging Therapies. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-500342
Modern Language Association (MLA)
Gómez, Karen…[et al.]. Medullary Thyroid Carcinoma : Molecular Signaling Pathways and Emerging Therapies. Journal of Thyroid Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-500342
American Medical Association (AMA)
Gómez, Karen& Varghese, Jeena& Jiménez, Camilo. Medullary Thyroid Carcinoma : Molecular Signaling Pathways and Emerging Therapies. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-500342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500342