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Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals
Joint Authors
Raghu, Madihalli Srinivas
Basavaiah, Kanakapura
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Two simple and rapid titrimetric methods are described for the determination of cyproheptadine hydrochloride (CPH) in pharmaceuticals.
The proposed methods are based on the solvent extraction-titration of CPH with two ion association reagents, sodium lauryl sulphate (SLS), (method A), and tetraphenylborate (TPB), (method B).
In method A, SLS was used as titrant and the titration was carried out in the presence of dilute sulphuric acid and chloroform using dimethyl yellow as indicator, whereas, in method B, the titrant was TPB and the titration was done in Walpole buffer of pH 4.5 and 1, 2-dichloroethane using tetrabromophenolphthalein ethyl ester as indicator.
The proposed procedures give sharp end points as the color of the organic phase changes from yellow to pink in method A, and from red-violet to yellow in method B.
The methods are applicable over the ranges of 1.0–20.0 and 2.0–9.0 mg of CPH for method A and method B, respectively.
The accuracy and precision of the methods are good.
The methods were applied successfully to the determination of CPH in tablets, and the results were in agreement with the label claim and those of the reference method.
American Psychological Association (APA)
Raghu, Madihalli Srinivas& Basavaiah, Kanakapura. 2012. Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500394
Modern Language Association (MLA)
Raghu, Madihalli Srinivas& Basavaiah, Kanakapura. Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals. ISRN Analytical Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-500394
American Medical Association (AMA)
Raghu, Madihalli Srinivas& Basavaiah, Kanakapura. Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500394