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Radioactive Iodine Therapy Decreases Recurrence in Thyroid Papillary Microcarcinoma
Joint Authors
Grigsby, Perry W.
Creach, Kimberly M.
Nussenbaum, Brian
Siegel, Barry A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The most appropriate therapy for papillary microcarcinoma (PMC) is controversial.
Methods.
We reviewed the therapy and outcome of 407 patients with PMC.
Results.
Three hundred-eighty patients underwent total thyroidectomy, and 349 patients received I-131 therapy.
The median followup was 5.3 years.
Forty patients developed recurrent disease.
On univariate analysis, development of disease recurrence was correlated with histological tumor size > 0.8 cm (P=0.0104), age < 45 years (P=0.043), and no I-131 therapy (P<0.0001).
On multivariate analysis, histological tumor size > 0.8 cm, positive lymph nodes, and no I-131 therapy were significant.
The 5-year RFS for patients treated with I-131 was 95.0% versus 78.6% (P<0.0001) for patients not treated with I-131.
Patients with lymph node metastasis who did not receive I-131 had a 5-year RFS of 42.9% versus 93.2% (P<0.0001) for patients who received I-131.
Conclusions.
Recommend I-131 remnant ablation for patients with PMC, particularly patients with lymph node metastasis.
American Psychological Association (APA)
Creach, Kimberly M.& Siegel, Barry A.& Nussenbaum, Brian& Grigsby, Perry W.. 2012. Radioactive Iodine Therapy Decreases Recurrence in Thyroid Papillary Microcarcinoma. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500398
Modern Language Association (MLA)
Creach, Kimberly M.…[et al.]. Radioactive Iodine Therapy Decreases Recurrence in Thyroid Papillary Microcarcinoma. ISRN Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-500398
American Medical Association (AMA)
Creach, Kimberly M.& Siegel, Barry A.& Nussenbaum, Brian& Grigsby, Perry W.. Radioactive Iodine Therapy Decreases Recurrence in Thyroid Papillary Microcarcinoma. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500398