Glioblastoma Presenting with Steroid-Induced Pseudoregression of Contrast Enhancement on Magnetic Resonance Imaging
Joint Authors
Fults, Daniel W.
Mazur, Marcus D.
Nguyen, Vinh
Source
Case Reports in Neurological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Corticosteroid-induced reduction in contrast enhancement on radiographic imaging is most commonly associated with lymphoma but has been reported in other entities, including glioma.
This finding may represent a diagnostic dilemma.
Concern that steroid-induced cytotoxicity obscures histological diagnosis of suspected lymphoma may lead to postponement of a biopsy.
If glioma is not considered in the differential diagnosis, reduction in tumor contrast enhancement may be misinterpreted as disease regression rather than a transient radiographic change.
We report a case of a patient with an enhancing right temporoparietal mass adjacent to the atrium of the lateral ventricle.
After treatment with dexamethasone was started, the mass exhibited marked reduction in contrast enhancement, with symptom improvement.
The clinical course suggested lymphoma, and surgery was not performed.
Subsequent screening for extra-axial lymphoma was negative.
Two weeks later, the patient developed worsening symptoms, and repeat T1-weighted imaging showed interval increase in size and enhancement.
The findings suggested a possible diagnosis of malignant glioma.
The patient underwent a stereotactic-guided craniotomy for excision of the right temporoparietal mass lesion.
Final histological diagnosis was glioblastoma multiforme, World Health Organization grade IV.
American Psychological Association (APA)
Mazur, Marcus D.& Nguyen, Vinh& Fults, Daniel W.. 2012. Glioblastoma Presenting with Steroid-Induced Pseudoregression of Contrast Enhancement on Magnetic Resonance Imaging. Case Reports in Neurological Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500438
Modern Language Association (MLA)
Mazur, Marcus D.…[et al.]. Glioblastoma Presenting with Steroid-Induced Pseudoregression of Contrast Enhancement on Magnetic Resonance Imaging. Case Reports in Neurological Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-500438
American Medical Association (AMA)
Mazur, Marcus D.& Nguyen, Vinh& Fults, Daniel W.. Glioblastoma Presenting with Steroid-Induced Pseudoregression of Contrast Enhancement on Magnetic Resonance Imaging. Case Reports in Neurological Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-500438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500438