![](/images/graphics-bg.png)
Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT
Joint Authors
Gurjarpadhye, Abhijit A.
Rylander, Christopher G.
Vogt, William C.
Liu, Yajing
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The highly disordered refractive index distribution in skin causes multiple scattering of incident light and limits optical imaging and therapeutic depth.
We hypothesize that localized mechanical compression reduces scattering by expulsing unbound water from the dermal collagen matrix, increasing protein concentration and decreasing the number of index mismatch interfaces between tissue constituents.
A swept-source optical coherence tomography (OCT) system was used to assess changes in thickness and group refractive index in ex vivo porcine skin, as well as changes in signal intensity profile when imaging in vivo human skin.
Compression of ex vivo porcine skin resulted in an effective strain of −58.5%, an increase in refractive index from 1.39 to 1.50, and a decrease in water volume fraction from 0.66 to 0.20.
In vivo OCT signal intensity increased by 1.5 dB at a depth of 1 mm, possibly due to transport of water away from the compressed regions.
These finding suggest that local compression could be used to enhance light-based diagnostic and therapeutic techniques.
American Psychological Association (APA)
Gurjarpadhye, Abhijit A.& Vogt, William C.& Liu, Yajing& Rylander, Christopher G.. 2011. Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500484
Modern Language Association (MLA)
Gurjarpadhye, Abhijit A.…[et al.]. Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-500484
American Medical Association (AMA)
Gurjarpadhye, Abhijit A.& Vogt, William C.& Liu, Yajing& Rylander, Christopher G.. Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT. International Journal of Biomedical Imaging. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500484