Severe Leptospirosis with Multiple Organ Failure Successfully Treated by Plasma Exchange and High-Volume Hemofiltration

Abstract EN

Background.

Leptospirosis is a spirochetal zoonosis with complex clinical features including renal and liver failure.

Case report.

We report the case of a Swiss fisherman presenting with leptospirosis.

After initial improvement, refractory septic shock and severe liver and kidney failure developed.

The expected mortality was estimated at 90% with clinical scores.

The patient underwent plasma exchanges and high-volume hemofiltration (HVHF) with complete recovery of hepatic and kidney functions.

Discussion.

Plasma exchanges and HVHF may confer survival benefit on patients with severe leptospirosis, refractory septic shock, and multiple-organ failure.