Stroma Targeting Nuclear Imaging and Radiopharmaceuticals
Joint Authors
Jeong, Jae-Min
Shim, Hyunsuk
Shetty, Dinesh
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Malignant transformation of tumor accompanies profound changes in the normal neighboring tissue, called tumor stroma.
The tumor stroma provides an environment favoring local tumor growth, invasion, and metastatic spreading.
Nuclear imaging (PET/SPECT) measures biochemical and physiologic functions in the human body.
In oncology, PET/SPECT is particularly useful for differentiating tumors from postsurgical changes or radiation necrosis, distinguishing benign from malignant lesions, identifying the optimal site for biopsy, staging cancers, and monitoring the response to therapy.
Indeed, PET/SPECT is a powerful, proven diagnostic imaging modality that displays information unobtainable through other anatomical imaging, such as CT or MRI.
When combined with coregistered CT data, [18F]fluorodeoxyglucose ([18F]FDG)-PET is particularly useful.
However, [18F]FDG is not a target-specific PET tracer.
This paper will review the tumor microenvironment targeting oncologic imaging such as angiogenesis, invasion, hypoxia, growth, and homing, and also therapeutic radiopharmaceuticals to provide a roadmap for additional applications of tumor imaging and therapy.
American Psychological Association (APA)
Shetty, Dinesh& Jeong, Jae-Min& Shim, Hyunsuk. 2012. Stroma Targeting Nuclear Imaging and Radiopharmaceuticals. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-500522
Modern Language Association (MLA)
Shetty, Dinesh…[et al.]. Stroma Targeting Nuclear Imaging and Radiopharmaceuticals. International Journal of Molecular Imaging No. 2012 (2012), pp.1-23.
https://search.emarefa.net/detail/BIM-500522
American Medical Association (AMA)
Shetty, Dinesh& Jeong, Jae-Min& Shim, Hyunsuk. Stroma Targeting Nuclear Imaging and Radiopharmaceuticals. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-500522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500522