Testosterone Increases : Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet
Joint Authors
Source
Advances in Pharmacological Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Estrogen (E) and testosterone (T) are important in the sexually dimorphic pattern of blood pressure (BP) development.
The goal was to examine the effects of endogenous E and exogenous T in the development of hypertension in female spontaneously hypertensive rats (SHR) on a high sodium diet.
Female SHR (N=27, 5-week) were divided into four groups: (1) control (n=8), (2) ovariectomized (OVX, n=26), (3) testosterone implants with intact ovaries (T, n=6), and (4) ovariectomized + testosterone implants (OVX+T, n=7).
T was given immediately after OVX and replaced every two weeks and they were fed a 3% NaCl diet.
BP was measured weekly and plasma norepinephrine (NE) analyzed by HPLC.
OVX+T females exhibited the greatest elevation in BP (190 ± 4.0 mmHg) compared to controls at 15 weeks of age (140 ± 3.4 mmHg, P<.001) and a pattern of hypertension development similar to that of male SHR.
Females with T treatment showed evidence of glomerulosclerosis.
In conclusion, T accelerated the development of hypertension similar to the BP pattern observed in males; the presence of ovaries attenuated the T induced increase in BP; T increased renal sodium reabsorption, and T increased glomerulosclerosis.
American Psychological Association (APA)
Liu, Bei& Ely, Daniel. 2011. Testosterone Increases : Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500528
Modern Language Association (MLA)
Liu, Bei& Ely, Daniel. Testosterone Increases : Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-500528
American Medical Association (AMA)
Liu, Bei& Ely, Daniel. Testosterone Increases : Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500528