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Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice
Joint Authors
Bhattarakosol, Parvapan
Patumraj, Suthiluk
Yoysungnoen-Chintana, Pornphrom
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To evaluate the effects of curcumin (CUR) on tumor progression and angiogenesis in cervical cancer- (CaSki-) implanted nude mice and on the angiogenic biomarkers: vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR).
CaSki cells were subcutaneously injected in nude mice to establish subcutaneous tumors.
One month after injection, mice were orally administered vehicle or 500, 1,000, and 1,500 mg/kg of CUR daily × 30 consecutive days.
Tumor volume was measured every 3-4 days.
At the end of the study, tumor microvasculature was observed under confocal microscope, and immunohistochemical analyses were performed to detect CD31, VEGF, COX-2, and EGFR.
CUR at the doses of 1,000 and 1,500 mg/kg showed significant tumor growth retardation (21.03% and 35.57%) versus CaSki + vehicle group.
The microvascular density (MVD) in CaSki + vehicle group was significantly increased versus Control + vehicle group and significantly reduced by CUR (1,000 and 1,500 mg/kg).
VEGF, COX-2, and EGFR expressions were upregulated in CaSki + vehicle group and attenuated significantly by CUR (1,000 and 1,500 mg/kg).
In conclusion, high dose CUR inhibited tumor growth and angiogenesis in CaSki-implanted mice probably mediated by the downregulation of VEGF, COX-2 and EGFR.
CUR may have a role in treating human cervical cancer and should be explored further.
American Psychological Association (APA)
Yoysungnoen-Chintana, Pornphrom& Bhattarakosol, Parvapan& Patumraj, Suthiluk. 2014. Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-500541
Modern Language Association (MLA)
Yoysungnoen-Chintana, Pornphrom…[et al.]. Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-500541
American Medical Association (AMA)
Yoysungnoen-Chintana, Pornphrom& Bhattarakosol, Parvapan& Patumraj, Suthiluk. Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-500541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500541