New Molecular Targeted Therapy and Redifferentiation Therapy for Radioiodine-Refractory Advanced Papillary Thyroid Carcinoma : Literature Review
Joint Authors
Wong, Kai-Pun
Lang, Brian Hung-Hin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although the majority of papillary thyroid carcinoma could be successfully managed by complete surgical resection alone or resection followed by radioiodine ablation, a small proportion of patients may develop radioiodine-refractory progressive disease which is not amenable to surgery, local ablative treatment or other treatment modalities.
The use of FDG-PET/CT scan for persistent/recurrent disease has improved the accuracy of restaging as well as cancer prognostication.
Given that patients with RAI-refractory disease tend to do significantly worse than those with radioiodine-avid or non-progressive disease, an increasing number of phase I and II studies have been conducted to evaluate the efficacy of new molecular targeted drugs such as the tyrosine kinase inhibitors and redifferentiation drugs.
The overall response rate of these drugs ranged between 0–53%, depending on whether the patients had been previously treated with these drugs, performance status and extent of disease.
However, drug toxicity remains a major concern in administration of target therapies.
Nevertheless, there are also ongoing phase III studies evaluating the efficacy of these new drugs.
The aim of the review was to summarize and discuss the results of these targeted drugs and redifferentiation agents for patients with progressive, radioiodine-refractory papillary thyroid carcinoma.
American Psychological Association (APA)
Wong, Kai-Pun& Lang, Brian Hung-Hin. 2012. New Molecular Targeted Therapy and Redifferentiation Therapy for Radioiodine-Refractory Advanced Papillary Thyroid Carcinoma : Literature Review. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-500555
Modern Language Association (MLA)
Wong, Kai-Pun& Lang, Brian Hung-Hin. New Molecular Targeted Therapy and Redifferentiation Therapy for Radioiodine-Refractory Advanced Papillary Thyroid Carcinoma : Literature Review. Journal of Thyroid Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-500555
American Medical Association (AMA)
Wong, Kai-Pun& Lang, Brian Hung-Hin. New Molecular Targeted Therapy and Redifferentiation Therapy for Radioiodine-Refractory Advanced Papillary Thyroid Carcinoma : Literature Review. Journal of Thyroid Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-500555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500555