Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered : Role of Tolvaptan
Joint Authors
Pende, Aldo
Dallegri, Franco
Oddo, Silvia
Artom, Nathan
Giusti, Massimo
Ottonello, Luciano
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The association between the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is rare and has never been treated with an arginine vasopressin receptor antagonist.
We report a unique case of SIADH associated with ibuprofen use and successfully treated with tolvaptan.
A 76-year-old man came to our observation because of lumbar pain and epigastric discomfort.
He was taking ibuprofen orally 400 mg bid as an analgesic treatment.
Laboratory tests showed low levels of sodium (116 mmol/L) and chloride; a diagnosis of SIADH was formulated and ibuprofen was stopped immediately.
Imaging tests allowed to rule out the presence of malignancies or cerebral and lung diseases.
Slightly hypertonic saline infusion was administered for 3 days without significant sodium improvement; therefore, tolvaptan was started at the initial dose of 7.5 mg daily, doubled after 5 days.
After 8 days of treatment the patient showed progressive increase of sodium levels up to normal values.
In the following weeks tolvaptan was prescribed at progressively titrated dosage to full suspension; afterwards the sodium levels remained normal without any type of treatment.
American Psychological Association (APA)
Artom, Nathan& Oddo, Silvia& Pende, Aldo& Ottonello, Luciano& Giusti, Massimo& Dallegri, Franco. 2013. Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered : Role of Tolvaptan. Case Reports in Endocrinology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500563
Modern Language Association (MLA)
Artom, Nathan…[et al.]. Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered : Role of Tolvaptan. Case Reports in Endocrinology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-500563
American Medical Association (AMA)
Artom, Nathan& Oddo, Silvia& Pende, Aldo& Ottonello, Luciano& Giusti, Massimo& Dallegri, Franco. Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered : Role of Tolvaptan. Case Reports in Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500563