Fatal Outcome of Disseminated Strongyloidiasis despite Detectable Plasma and Cerebrospinal Levels of Orally Administered Ivermectin
Joint Authors
Dougherty, Mark J.
Paciullo, Christopher A.
Fleckenstein, Lawrence L.
Kelly, David R.
Rose, Charles E.
Source
Journal of Parasitology Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Strongyloides stercoralis affects over 100 million people worldwide.
Those people most susceptible to infection are those with an immunocompromising condition, such as cancer or human immunodeficiency virus (HIV).
Local disease may spread throughout the body of the host, causing a condition termed disseminated strongyloidiasis.
Standard treatment for Strongyloides stercoralis infection is oral ivermectin.
We describe a patient with chronic lymphocytic leukemia diagnosed with disseminated strongyloidiasis two weeks after initial presentation.
After repeated dosing of oral ivermectin with no clinical response, serum and cerebral spinal fluid (CSF) concentrations of ivermectin were measured to assess absorption.
The peak serum concentration of 49.3 ng/mL correlated with a CSF concentration of 0.14 ng/mL.
Despite these concentrations, the patient eventually succumbed to multi-system organ failure.
We discuss the reasons for treatment failure and explore the utility of measuring ivermectin concentrations.
American Psychological Association (APA)
Rose, Charles E.& Paciullo, Christopher A.& Kelly, David R.& Dougherty, Mark J.& Fleckenstein, Lawrence L.. 2009. Fatal Outcome of Disseminated Strongyloidiasis despite Detectable Plasma and Cerebrospinal Levels of Orally Administered Ivermectin. Journal of Parasitology Research،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-500566
Modern Language Association (MLA)
Rose, Charles E.…[et al.]. Fatal Outcome of Disseminated Strongyloidiasis despite Detectable Plasma and Cerebrospinal Levels of Orally Administered Ivermectin. Journal of Parasitology Research No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-500566
American Medical Association (AMA)
Rose, Charles E.& Paciullo, Christopher A.& Kelly, David R.& Dougherty, Mark J.& Fleckenstein, Lawrence L.. Fatal Outcome of Disseminated Strongyloidiasis despite Detectable Plasma and Cerebrospinal Levels of Orally Administered Ivermectin. Journal of Parasitology Research. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-500566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500566