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Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents
Joint Authors
Sawada, Hajime
Akimoto, Yoshihiro
Ohara-Imaizumi, Mica
Nagamatsu, Shinya
Kawakami, Hayato
Source
Experimental Diabetes Research
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We examined changes in the ultrastructure and localization of major extracellular matrix components, including 5 types of collagen (type I, III, IV, VI, and VIII), laminin, fibronectin, and heparan sulfate proteoglycan in Descemet's membrane of the cornea of diabetic GK rats.
In the cornea of diabetic GK rats, more long-spacing collagen fibrils were observed in Descemet's membrane than in the membrane of the nondiabetic Wistar rats.
Both GK and Wistar rats showed an age-dependent increase in the density of the long-spacing collagen.
Immunoelectron microscopy showed that type VIII collagen was localized in the internodal region of the long-spacing collagen, which was not labelled by any of the other antibodies used.
The antidiabetic agents nateglinide and glibenclamide significantly suppressed the formation of the long-spacing collagen in the diabetic rats.
Long-spacing collagen would thus be a useful indicator for studying diabetic changes in the cornea and the effect of antidiabetic agents.
American Psychological Association (APA)
Akimoto, Yoshihiro& Sawada, Hajime& Ohara-Imaizumi, Mica& Nagamatsu, Shinya& Kawakami, Hayato. 2008. Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents. Experimental Diabetes Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-500568
Modern Language Association (MLA)
Akimoto, Yoshihiro…[et al.]. Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents. Experimental Diabetes Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-500568
American Medical Association (AMA)
Akimoto, Yoshihiro& Sawada, Hajime& Ohara-Imaizumi, Mica& Nagamatsu, Shinya& Kawakami, Hayato. Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents. Experimental Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-500568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500568