Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent
Joint Authors
Raghu, Madihalli Srinivas
Prashanth, Kudige Nagaraj
Ramesh, Pavagada J.
Vinay, Kanakapura B.
Basavaiah, Kanakapura
Xavier, Cijo M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Titrimetric and spectrophotometric assay of ganciclovir (GNC) is described using cerium(IV) sulphate as the oxidimetric reagent.
The methods are based on the oxidation of GNC with a measured excess of cerium(IV) sulphate in acid medium followed by determination of the unreacted oxidant by two different reaction schemes.
In titrimetry, the unreacted oxidant was determined by back titration with ferrous ammonium sulphate (FAS) in sulphuric acid medium, and spectrophotometry involves the reaction of residual cerium(IV) with p-DMAB to form brownish-coloured p-dimethylamino quinoneimine whose absorbance was measured at 460 nm.
In both methods, the amount of cerium(IV) sulphate reacted corresponds to GNC concentration.
Titrimetry is applicable over 3–10 mg range where as, in spcetrophotometry, the calibration graph is linear over the range of 2–10 μg mL−1 and the calculated molar absorptivity value is 1.960×104 L mol−1 cm−1.
The validity of the proposed methods was tested by analyzing pure and dosage forms containing GNC.
Statistical treatment of the results reflects that the proposed procedures are precise, accurate, and easily applicable for the determination of GNC pure form and in pharmaceutical formulations.
American Psychological Association (APA)
Ramesh, Pavagada J.& Basavaiah, Kanakapura& Xavier, Cijo M.& Prashanth, Kudige Nagaraj& Raghu, Madihalli Srinivas& Vinay, Kanakapura B.. 2012. Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-500570
Modern Language Association (MLA)
Ramesh, Pavagada J.…[et al.]. Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent. ISRN Analytical Chemistry No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-500570
American Medical Association (AMA)
Ramesh, Pavagada J.& Basavaiah, Kanakapura& Xavier, Cijo M.& Prashanth, Kudige Nagaraj& Raghu, Madihalli Srinivas& Vinay, Kanakapura B.. Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-500570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500570